Clinical Studies of Silymarin as a Protective Agent Against Liver Damage Caused by Anti-TB Drugs, Methotrexate, and in Cases of Chronic Hepatitis C and Diabetes Mellitus

The liver is the organ in charge of homeostasis and metabolism sundry substances (endogenous exogenous, including drugs); but when these are metabolized, they generate more toxic and/or reactive metabolites, that can damage causing cirrhosis, steatosis hepatocarcinoma. Human have been used several medicinal plants (MP) since ancestral times to treat their ailments, diseases disorders, Sylibum marianum. This MP treatment jaundice other biliary diseases, as well support therapy for edible mushrooms poisoning some hepatic diseases. From this plant, silymarin (SLM, mixture flavonoids) obtained, it has an important antioxidant, anti-inflammatory hepatoprotector effect. last activity demonstrated through preclinical clinical studies. To date, a few studies describe hepatoprotective nephroprotective effect SLM against caused by anti- TB drugs, methotrexate cases type II diabetes mellitus or chronic hepatitis C. Nevertheless, research frequent trials (using rats mice) vitro assay.